期刊
JOURNAL OF ETHNOPHARMACOLOGY
卷 96, 期 3, 页码 411-415出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2004.09.041
关键词
Psidium guajava; type 2 diabetes; PTP1B; Lepr(db)/Lepr(db) mice; blood glucose
During a screening of medicinal plants for inhibition of protein tyrosine phosphatase1B (PTP1B), an extract from Psidium guajava (Myrtaceae) leaves exhibited significant inhibitory effect on PTP1B. Thus, its antidiabetic effect on Lepr(db)/Lepr(db) mice was evaluated. Significant blood glucose lowering effects of the extract were observed after intraperitoneal injection of the extract at a dose of 10 mg/kg in both 1- and 3-month-old Lepr(db)/Lepr(db) mice. In addition, histological analysis of the liver from the butanol-soluble fraction treated Lepr(db)/Lepr(db) mice revealed a significant decrease in the number of lipid droplets compared to the control mice. Taken together, it was suggested that the extract from Psidium guajava leaves possesses antidiabetic effect in type 2 diabetic mice model and these effect is, at least in part, mediated via the inhibition of PTP1B. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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