Interleukin-8, intercellular adhesion molecule-1 and tumour necrosis factor-α gene polymorphisms and the risk for multiple system atrophy

In a case-control study using a clinically well-defined group of 41 multiple system atrophy (MSA) patients and 93 control subjects. the interleukin (IL)-8 (-251) TT genotype was associated with an approximately fourfold increased risk for MSA and, furthermore. this risk increased elevenfold with the simultaneous presence of the intercellular adhesion molecule-1 (ICAM-1: E469K) KK genotype suggesting a a gene-gene interaction. These data support a role for inflammation-related genes in risk for MSA. (C) 2004 Elsevier B.V. All rights reserved.