期刊
NEUROIMAGE
卷 24, 期 2, 页码 548-559出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2004.08.026
关键词
magnetic resonance diffusion-weighted imaging; perfusion weighted imaging; reading; dyslexia; fusiform gyrus
资金
- NCRR NIH HHS [P41 RR15241] Funding Source: Medline
- NIDCD NIH HHS [R01 DC005375, R01 DC05375] Funding Source: Medline
- NINDS NIH HHS [R01 NS047691] Funding Source: Medline
Activation of the left midfusiform gyrus in response to reading words and pseudowords is such a reliable finding in functional imaging that this region has been called the visual word form area (VWFA). However, this label has recently been challenged, because activation in VWFA is also observed in other lexical tasks. We evaluated whether VWFA is necessary sufficient, or specialized for reading by examining ning how frequently acute lesions in VWFA disrupt tasks that require access to written word forms versus other lexical tasks. We administered lexical tasks with spoken and written input and output, and identified damage or dysfunction of VWFA and other regions of interest (ROI) on diffusion- and perfusion-weighted imaging (DWI and PWI) in 80 patients within 24h of onset of acute left ischemic stroke. Associations between abnormalities in each region of interest and impairment on lexical tasks were evaluated with chi-squared tests. Damage or dysfunction of VWFA was not significantly associated with impairment of written word comprehension or lexical decision, but was significantly associated with impairment on all tasks requiring lexical output: oral reading and oral naming (visual or tactile input), and written naming. We account for these results and results from functional imaging by proposing that the left midfusiform gyrus normally has two roles in reading: (1) computation of location- and modality-independent grapheme sequences from written word stimuli, and (2) a modality-independent stage of lexical processing that links modality-specific input and output representations. VWFA is not necessary for the former because the right homologue of VWFA can immediately assume this role. (C) 2004 Elsevier Inc. All rights reserved.
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