期刊
CANCER
卷 103, 期 2, 页码 237-241出版社
WILEY
DOI: 10.1002/cncr.20766
关键词
osteoporosis; androgen deprivation therapy; prostate carcinoma; dualenergy X-ray absorptiometry
类别
BACKGROUND. Androgen deprivation therapy (ADT) is a strong risk factor for osteoporosis. The Current study identified physician practices in preventing or treating osteoporosis during ADT. The practices of interest are the uses of dual-energy X-ray absorptiometry (DXA) scans, bisphosphonates, calcium or vitamin D supplement, calcitonin, or estrogen. METHODS. A retrospective medical record review was conducted. Patients were included if they had received ADT with goserelin injection for greater than or equal to 1 year. Multivariable logistic regression analysis was performed to identify independent predictors of receiving at least one intervention. RESULTS. Analyses included 184 patients. Most were the elderly with multiple risk factors for osteoporosis. Only 8.7% (95% confidence interval [CI], 4.6-13.0%) of patients received a DXA scan at least once during the past 3 years. Oral and intravenous bisphosphonates were prescribed in 4.9% (95%Cl, 1.8-8.0%) and 0.5% (95%Cl, 0-2.0%) of patients, respectively, during the past year. Overall, 14.7% of patients (95%Cl, 9.5-20.0%) received at least one intervention. Concurrent risk factors for osteoporosis, including smoking, alcoholism, advanced age, low body mass index, long duration of ADT, multiple comorbidities, history of fractures, and steroid use, were not independent predictors of having received interventions. However, bone metastasis was, with a hazard ratio of 5.6 (95%C1, 1.99-15.60%). Primary care physicians provided the greatest number of interventions and cancer-related specialists provided the fewest. CONCLUSIONS. The majority of patients with prostate carcinoma undergoing ADT did not receive interventions to prevent or treat osteoporosis. Having other concurrent risk factors for osteoporosis was not predictive of receiving these few interventions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据