期刊
JOURNAL OF ETHNOPHARMACOLOGY
卷 96, 期 3, 页码 477-482出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jep.2004.09.047
关键词
acetylcholine; acetylcholinesterase; antistressor; cholinergic system; noise stress; Ocimum sanctum
The ethanolic extract from the leaves of Ocimum sanctum Linn was screened for its effects on the noise induced changes in the central cholinergic system of albino rats by investigating the acetylcholine content and acetylcholinesterase activity in discrete areas of brain. Exposure to noise (10 kHz: 100 dB) stress for 30 min caused a significant reduction in total acetylcholine content and increase in the activity of acetylcholinesterase in cerebral cortex, corpus striatum, hypothalamus and hippocampus of brain. Pretreatment of the animals with ethanol extract of Ocimum sanctum leaves for 7 days prevented the noise induced changes in these two cholinergic parameters in all the four areas of brain. The results of the study indicate the protective nature of the plant material on the brain tissues against the detrimental effect of noise stress. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据