期刊
FEBS LETTERS
卷 579, 期 2, 页码 473-476出版社
WILEY
DOI: 10.1016/j.febslet.2004.12.014
关键词
endothelial cell; cytoskeletal dynamics; atomic force microscopy; mechanotransduction
资金
- NHLBI NIH HHS [HL076241] Funding Source: Medline
The cortical cytoskeleton of vascular endothelial cells plays an important role in responding to mechanical stimuli and controlling the distribution of cell surface proteins. Here, we have used atomic force microscopy to visualize the dynamics of cortical cytoskeleton in living bovine pulmonary artery endothelial cells. We demonstrate that the cortical cytoskeleton, organized as a complex polygonal mesh, is highly dynamic and shows two modes of remodeling: intact-boundary-mode where mesh element boundaries remain intact but move at similar to0.08 mum/min allowing the mesh element to change shape, and altered-boundary-mode where new mesh boundaries form and existing ones disappear. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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