期刊
BRITISH JOURNAL OF CANCER
卷 92, 期 1, 页码 7-12出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjc.6602229
关键词
cell cycle; targeted therapy
类别
Cell division involves a cyclical biochemical process composed of several step-wise reactions that have to occur once per cell cycle. Dysregulation of cell division is a hallmark of all cancers. Genetic and epigenetic mechanisms frequently result in deranged expression and/or activity of cell-cycle proteins including the cyclins, cyclin-dependent kinases (Cdks), Cdk inhibitors and checkpoint control proteins. The critical nature of these proteins in cell cycling raises hope that targeting them may result in selective cytotoxicity and valuable anticancer activity.
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