期刊
AQUATIC TOXICOLOGY
卷 71, 期 1, 页码 49-59出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aquatox.2004.10.012
关键词
Xenobiotic mixture; synergistic effects; PCB; TBT; swimming behavior; biotransformation
The sensitivity of carp to chronical stress due to single and combined mixtures (each 50%) of TBT and PCB was evaluated under laboratory conditions. And concluded, mixed exposures were partially more or less toxic than single ones. Xenobiotic stress led to both decreased mean daily swimming speed and an increased mean swimming speed during darkness. Also a decreased preferred swimming depth (nearer to the surface) during nighttime was observed. We found approximately synergistic effects of TBT and PCB in swimming behavior of carp exposed to those mixtures. PCB did not affect the body growth significantly. TBT-stress led to a decreased body growth and the exposure to PCB-TBT mixture caused an approximately additive decrease. of body growth. Measurement of biotransformation potential measured as GST enzyme activity showed both increasing or decreasing activity levels after exposure to single and mixture chemical combinations (approximately additive. antagonistic and synergistic). Nevertheless, we had to conclude that all methods tested were useful to screen subacute effects of single as well as mixed xenobiotic chemicals on carp, which is the prerequisite for an investigation of samples taken from the environment. (C) 2004 Elsevier B.V. All rights reserved.
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