期刊
NEUROREPORT
卷 16, 期 1, 页码 73-76出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200501190-00017
关键词
axons; diffusion MRI; spinal cord
资金
- NIMH NIH HHS [MH62009] Funding Source: Medline
- NINDS NIH HHS [NS24707, NS41380, NS02230] Funding Source: Medline
Following spinal cord injury, diffusion MRI (DWI) has been shown to detect injury and functionally significant neuroprotection following treatment that otherwise would go undetected with conventional MRI. The underlying histologic correlates to directional apparent diffusion coefficients (ADC) obtained with DWI have not been determined, however, and we address this issue by directly correlating ADC values with corresponding axon morphometry in the normal rat cervical spinal cord. ADC values transverse (perpendicular) and longitudinal (parallel) to axons both correlate with axon counts, however each directional ADC reflects distinct histologic parameters. DWI may therefore be capable of providing specific histologic data regarding the integrity of white matter. (C) 2005 Lippincott Williams Wilkins.
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