期刊
CANCER LETTERS
卷 217, 期 2, 页码 139-147出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2004.07.021
关键词
DNA polymerase; human lung cancer; stomach cancer; colorectal cancer
类别
Human DNA polymerases kappa, eta, iota, and zeta are responsible for the translesion DNA synthesis. Numerous in vitro studies indicated that these enzymes may contribute to DNA lesion-triggered and spontaneous mutation. We measured the transcripts of these 4 enzymes in 131 self-paired cancerous and non-tumor samples, including 23 lung cancers, 49 stomach cancers, and 59 colorectal cancers. Our results indicated that, except pol eta in colorectal cancers, these enzymes are all significantly down-regulated in human lung, stomach, and colorectal cancers, suggesting that these enzymes are probably not closely associated with the elevated mutations in human cancer. (C) 2004 Elsevier Ireland Ltd. All rights reserved.
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