期刊
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
卷 314, 期 17, 页码 1818-1831出版社
AMER MEDICAL ASSOC
DOI: 10.1001/jama.2015.13766
关键词
-
资金
- National Cancer Institute [T32 CA 009001]
- National Institute of Diabetes and Digestive and Kidney Diseases [K24 DK098311]
- Harvard Catalyst-The Harvard Clinical and Translational Science Center (National Center for Research Resources)
- Harvard Catalyst-The Harvard Clinical and Translational Science Center (National Center for Advancing Translational Sciences, National Institutes of Health) [UL1 TR001102]
- Harvard University
IMPORTANCE It is important to document patterns of prescription drug use to inform both clinical practice and research. OBJECTIVE To evaluate trends in prescription drug use among adults living in the United States. DESIGN, SETTING, AND PARTICIPANTS Temporal trends in prescription drug use were evaluated using nationally representative data from the National Health and Nutrition Examination Survey (NHANES). Participants included 37 959 noninstitutionalized US adults, aged 20 years and older. Seven NHANES cycles were included (1999-2000 to 2011-2012), and the sample size per cycle ranged from 4861 to 6212. EXPOSURES Calendar year, as represented by continuous NHANES cycle. MAIN OUTCOMES AND MEASURES Within each NHANES cycle, use of prescription drugs in the prior 30 days was assessed overall and by drug class. Temporal trends across cycles were evaluated. Analyses were weighted to represent the US adult population. RESULTS Results indicate an increase in overall use of prescription drugs among US adults between 1999-2000 and 2011-2012 with an estimated 51% of US adults reporting use of any prescription drugs in 1999-2000 and an estimated 59% reporting use of any prescription drugs in 2011-2012 (difference, 8%[95% CI, 3.8%-12%]; P for trend <. 001). The prevalence of polypharmacy (use of >= 5 prescription drugs) increased from an estimated 8.2% in 1999-2000 to 15% in 2011-2012 (difference, 6.6%[95% CI, 4.4%-8.2%]; P for trend <. 001). These trends remained statistically significant with age adjustment. Among the 18 drug classes used by more than 2.5% of the population at any point over the study period, the prevalence of use increased in 11 drug classes including antihyperlipidemic agents, antidepressants, prescription proton-pump inhibitors, and muscle relaxants. CONCLUSIONS AND RELEVANCE In this nationally representative survey, significant increases in overall prescription drug use and polypharmacy were observed. These increases persisted after accounting for changes in the age distribution of the population. The prevalence of prescription drug use increased in the majority of, but not all, drug classes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据