期刊
NEURON
卷 45, 期 2, 页码 293-300出版社
CELL PRESS
DOI: 10.1016/j.neuron.2004.12.038
关键词
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资金
- NEI NIH HHS [EY013010] Funding Source: Medline
- NIGMS NIH HHS [GM063911] Funding Source: Medline
Circadian pacemaker neurons contain a molecular clock that oscillates with a period of similar to24 hr, controlling circadian rhythms of behavior. Pacemaker neurons respond to visual system inputs for clock resetting, but, unlike other neurons, have not been reported to transmit rapid signals to their targets. Here we show that pacemaker neurons are required to mediate a rapid behavior. The Drosophila larval visual system, Bolwig's organ (BO), projects to larval pacemaker neurons to entrain their clock. BO also mediates larval photophobic behavior. We found that ablation or electrical silencing of larval pacemaker neurons abolished light avoidance. Thus, circadian pacemaker neurons receive input from BO not only to reset the clock but also to transmit rapid photophobic signals. Furthermore, as clock gene mutations also affect photophobicity, the pacemaker neurons modulate the sensitivity of larvae to light, generating a circadian rhythm in visual sensitivity.
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