期刊
PHYSICS IN MEDICINE AND BIOLOGY
卷 50, 期 2, 页码 215-229出版社
IOP PUBLISHING LTD
DOI: 10.1088/0031-9155/50/2/003
关键词
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资金
- NHLBI NIH HHS [5R01HL071762, 5R01HL071635] Funding Source: Medline
Voltage-sensitive dyes are an important tool in visualizing electrical activity in cardiac tissue. Until today, they have mainly been applied in cardiac electrophysiology to subsurface imaging. In the present study, we assess different imaging methods used in optical tomography with respect to their effectiveness in visualizing 3D cardiac activity. To achieve this goal, we simulate optical signals produced by excitation fronts initiated at different depths inside the myocardial wall and compare their properties for various imaging modes. Specifically, we consider scanning and broad-field illumination, including trans- and epi-illumination. We focus on the lateral optical resolution and signal intensity, as a function of the source depth. Optical diffusion theory is applied to derive a computationally efficient approximation of the point-spread function and to predict voltage-sensitive signals. Computations were performed both for fluorescent and absorptive voltagesensitive dyes. Among all the above-inentioned methods, fluorescent coaxial scanning yields the best resolution (<2.5 mm) and gives the most information about the intramural cardiac activity.
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