期刊
JOURNAL OF COMPARATIVE NEUROLOGY
卷 481, 期 4, 页码 352-362出版社
WILEY
DOI: 10.1002/cne.20389
关键词
Na channel; SNAP25; monoamine vesicular transporter
资金
- NEI NIH HHS [EY 03570] Funding Source: Medline
- NINDS NIH HHS [NS 25134] Funding Source: Medline
We examined developmental changes in dopaminergic (DA) neurons of rat pups between postnatal (P) days 3 and 21. DA cell bodies and dendrites grew progressively between P3-15. Voltage-sensitive sodium channels were present in axons at P11, but the ring-like DA axon terminals appeared only during the third postnatal week. The density of ring terminals increased markedly between P15 and P21. The vesicular monoamine transporter (VMAT2) was absent before P13, and became concentrated in DA ring terminals after P17. A steady increase in VMAT2-containing rings around AII amacrine cells occurred during the third postnatal week. The presynaptic membrane protein SNAP-25 colocalized with DA terminals, but several other presynaptic proteins tested, including synaptotagmin I, synapsin, bassoon, syntaxin, and synaptogyrin, appeared not to be associated with DA neurons. Our study shows that the somatodendritic compartment of DA neurons matures before the DA axon terminals do. Maturation of DA axons during the third postnatal week corresponds to the period of onset of visual function. (C) 2004 Wiley-Liss, Inc.
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