期刊
CURRENT BIOLOGY
卷 15, 期 2, 页码 122-128出版社
CELL PRESS
DOI: 10.1016/j.cub.2005.01.006
关键词
-
资金
- Wellcome Trust [067453, 073735, 061140] Funding Source: Medline
Controversy surrounds the role of human medial frontal cortex in controlling actions [1-5]. Although damage to this area leads to severe difficulties in spontaneously initiating actions [6], the precise mechanisms underlying such volitional deficits remain to be established. Previous studies have implicated the medial frontal cortex in conflict monitoring [7-10] and the control of voluntary action [111, 12], suggesting that these key processes are functionally related or share neural substrates. Here, we combine a novel behavioral paradigm with functional imaging of the oculomotor system to reveal, for the first time, a functional subdivision of the pre-supplementary motor area (pre-SMA) into anatomically distinct areas that respond exclusively to either volition or conflict. We also demonstrate that activity in the supplementary eye field (SEF) distinguishes between success and failure in changing voluntary action plans during conflict, suggesting a role for the SEF in implementing the resolution of conflicting actions. We propose a functional architecture of human medial frontal cortex that incorporates the generation of action plans and the resolution of conflict.
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