期刊
TETRAHEDRON
卷 61, 期 5, 页码 1199-1206出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2004.11.039
关键词
cell-based assay; double strand break repair; steroidal glycoside; modified Mosher's method; catalytic hydrogenation
Bioassay-guided fractionation of the methanol extract of Erylus lendenfeldi using engineered strains of budding yeast (Saccharomyces cerevisiae) has resulted in the isolation of the known compound eryloside A (1) and two new compounds, erylosides K (2) and L (3). The structures were established based mainly on 1D and 2D NMR data. The absolute stereochemistry of eryloside A, which had never been fully characterized, was determined using the modified Mosher's method. The absolute stereochemistry of eryloside K was determined by comparison with tetrahydroeryloside A. Compounds 1-3 exhibited selective cytotoxicity against a yeast strain (Deltarad50) deficient in double strand break (DSB) repair. (C) 2004 Elsevier Ltd. All rights reserved.
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