期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 347, 期 2-3, 页码 417-425出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200404319
关键词
asymmetric alkylation; asymmetric catalysis; chiral amines; hafnium; imines; zirconium
Readily available chiral amino acid-based ligands are used in metal-catalyzed additions of alkyl-zinc reagents to various aromatic and aliphatic imines; the desired amine products are formed efficiently and in high levels of optical purity. In cases where the more Lewis acidic Zr salts afford lower efficiency, Hf-based catalysts deliver significantly higher yields with similar enantioselectivities. Critical structural features of the N-activating groups as well as the optimal chiral ligands are discussed. A mechanistic working model is presented to rationalize the existing data and to serve as a predictive tool.
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