期刊
EUROPEAN JOURNAL OF CANCER
卷 41, 期 3, 页码 411-415出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ejca.2004.09.030
关键词
prostate cancer; screening; overdiagnosis
类别
The rate of overdiagnosis of prostate carcinoma was assessed by following 6890 participants in pilot screening studies from 1991 to 1994. Observed/expected incidence and mortality were determined using data from the Cancer and Mortality Registry. The cancer detection rate (1.75%) and observed/expected ratio (12.5:1) were high at the first screening, and substantially lower at the second screening (0.65% or 4.10:1). According to the registry follow-up, prostate cancer occurred in 225 subjects in the whole study cohort, while 178.2 were expected with 50 652 men/years at risk. The standardised incidence rate was 1.66 in the screened (95%CI = 1.4-2.0), 0.97 in the non-responders (95%CI = 0.8-1.2) and 1.23 in subjects excluded from invitation due to previous cancer or major illness (95%CIl = 0.8-1.5). A 66% excess incidence rate was observed in the screened subjects over a 9-year period, confirming previous estimates of overdiagnosis. (C) 2004 Elsevier Ltd. All rights reserved.
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