期刊
COMPTES RENDUS BIOLOGIES
卷 328, 期 2, 页码 131-142出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.crvi.2004.10.009
关键词
Parkinson's disease; environmental factors; familial Parkinsonian syndromes; ubiquitin-proteasome pathway; mitochondria
类别
Parkinson's disease (PD) is a common age-related, progressive neurodegenerative disease of unknown etiology. Environmental factors have long been suspected to participate in the pathogenesis of PD due to the existence of neurotoxins that preferentially damage the dopaminergic nigrostriatal pathway. In the past few years, novel insights into the degenerative process have been provided by the discovery of genes responsible for rare monogenic parkinsonian syndromes. Compelling evidence is accumulating, suggesting that the products of several of these genes can interact with environmental toxins and intervene in molecular pathways controlling the functional integrity of mitochondria. (C) 2004 Academie des sciences. Published by Elsevier SAS. All rights reserved.
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