期刊
NATURE REVIEWS CANCER
卷 5, 期 2, 页码 135-141出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc1548
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Multiple conserved mechanisms limit DNA replication to once per cell cycle. One vital level of control focuses on the loading of the heterohexameric ring of minichromosome maintenance proteins (MCMs) onto chromatin in the hierarchical assembly of the pre-replication complex at origins of replication. An essential role in proliferation for MCMs and their regulators makes them potentially important biomarkers for routine clinical use in cancer detection and prognosis.
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