期刊
EXPERIMENTAL NEUROLOGY
卷 191, 期 -, 页码 S95-S103出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2004.06.017
关键词
dementia with Lewy bodies; Alzheimer's disease; positron emission tomography; [F-18]fluorodeoxyglucose; local cerebral metabolic rate for glucose; magnetic resonance imaging; neuropsychological testing
资金
- NIA NIH HHS [P50 AG08671] Funding Source: Medline
- NINDS NIH HHS [P01 NS15655] Funding Source: Medline
We compared the relative utility of neuropsychological testing and positron emission tomography (PET) with [F-18]fluorodeoxyglucose ([F-18]FDG) in differentiating Alzheimer's disease (AD) from dementia with Lewy bodies (DLB). We studied 25 patients with AD, 20 with DLB, and 19 normal elderly controls. There was no difference between patient groups for MMSE, confrontational naming, or verbal learning. The DLB group was significantly more impaired than the AD group for verbal fluency, and the AD group was significantly more impaired than the DLB group for verbal delayed recall. The DLB group had greater difficulty than the AD group on a visual discrimination task that does not require motor functioning, but the difference did not reach significance. Family ratings of motor functioning suggested significantly greater impairment in DLB patients than in AD patients. PET studies revealed significantly lower local cerebral metabolic rates for glucose (ICMRglc) for visual cortex (Brodmann areas 17, 18, and 19) in the DLB than the AD group, but no differences for other regions commonly affected in AD, including posterior cingulate, superior parietal lobe, lateral temporal lobe, and the prefrontal region. Motor ratings were significantly correlated with 1CMRglc in all areas of cerebral cortex, including Brodmann areas 17, 18, and 19. The results demonstrate a similar profile of cerebral hypometabolism in the two patient groups except in the visual cortex, where the DLB group shows markedly lower ICMRglc than the AD group. Neuropsychological testing also differentiates the groups, and family ratings of motor functioning are as robust as PET in these later stages of the disorders. (C) 2004 Elsevier Inc. All rights reserved.
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