期刊
CELL RESEARCH
卷 15, 期 2, 页码 92-96出版社
INST BIOCHEMISTRY & CELL BIOLOGY
DOI: 10.1038/sj.cr.7290271
关键词
cancer; cell cycle; KLF; transcription; transformation; zinc fingers
类别
资金
- NCI NIH HHS [CA84197, R01 CA084197] Funding Source: Medline
- NIDDK NIH HHS [DK64399, DK52230, R24 DK064399, R01 DK052230] Funding Source: Medline
- NIGMS NIH HHS [T32 GM008169] Funding Source: Medline
Kruppel-like factors (KLFs) are evolutionarily conserved zinc finger-containing transcription factors with diverse regulatory functions in cell growth, proliferation, differentiation, and embryogenesis. KLF4 and KLF5 are two closely related members of the KLF family that have a similar tissue distribution in embryos and adults. However, the two KLFs often exhibit opposite effects on regulation of gene transcription, despite binding to similar, if not identical, cis-acting DNA sequences. In addition, KLF4 and 5 exert contrasting effects on cell proliferation in many instances; while KLF4 is an inhibitor of cell growth, KLF5 stimulates proliferation. Here we review the biological properties and biochemical mechanisms of action of the two KLFs in the context of growth regulation.
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