期刊
AMERICAN JOURNAL OF OPHTHALMOLOGY
卷 139, 期 2, 页码 302-310出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ajo.2004.09.046
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资金
- NEI NIH HHS [EY04853] Funding Source: Medline
PURPOSE: To report vitreous oxygen tension before, immediately after, and at longer times after vitrectomy. DESIGN: A prospective, interventional consecutive case series. METHODS: Oxygen was measured using an optical oxygen sensor in patients undergoing vitrectomy. Intraoperatively, oxygen measurements were taken before and after vitrectomy in two intraocular locations: adjacent to the lens and in the mid-vitreous. RESULTS: Sixty-nine eyes underwent oxygen tension measurements at the time of vitrectomy. In baseline eyes, oxygen tension in the vitreous was low, measuring 8.7 +/- 0.6 mm Hg adjacent to the lens and 7.1 +/- 0.5 mm Hg in the mid,vitreous. The difference between the two locations was statistically significant (P <.003), indicating that vitreous gel maintains an intraocular oxygen gradient. Immediately after vitrectomy, oxygen tension in the fluid-filled eye was higher, measuring 69.6 +/- 4.8 mm Hg adjacent to the lens and 75.6 +/- 4.1 mm Hg in the mid,vitreous. There was no statistically significant oxygen gradient between the two locations. The difference in oxygen tension pre, and postvitrectomy is highly statistically significant (P <.0001 lens, P <.0001 mid-vitreous). In eyes with a history of vitrectomy and previous removal of the vitreous gel, the intraocular oxygen tension was significantly higher than in eyes with a formed vitreous gel undergoing a first vitrectomy (P <.02 lens, P <.003 mid-vitreous). CONCLUSION: Vitrectomy surgery significantly increases intraocular oxygen tension during and for prolonged periods after surgery. This exposes the crystalline lens to abnormally high oxygen and may lead to nuclear cataract formation.
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