期刊
CURRENT OPINION IN PEDIATRICS
卷 17, 期 1, 页码 56-61出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.mop.0000151781.13635.70
关键词
serious bacterial infections; white blood cell count; C-reactive protein; procalcitonin; interleukin-6
类别
Purpose of review Evaluation of a febrile infant or child for serious bacterial infections (SBI) can be a challenging task; there is no single reliable predictor of SBI in infants. This review examines some of the recent work evaluating the usefulness of indicators for SBI, such as white blood cell count (WBC), C-reactive protein (CRP), procalcitonin (PCT), and interleukin-6 (IL-6). Recent findings While WBC is traditionally used as an indicator of serious infection, it appears to be the lest specific and sensitive test in children. CRP and PCT are the most promising, but neither is an ideal single indicator by itself, especially in infants. There has been very limited experience with PCT in this country, however, IL-6 is more useful than WBC but less accurate than either CRP or PCT. Summary Much progress has been made in recent years in finding more accurate indicators of SBI than WBC. However, while recent developments have given clinicians some new tools in evaluating febrile infants and children, it remains a formidable undertaking. In the especially vulnerable infant population, the holy grail of a single ideal SBI indicator remains elusive.
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