期刊
CURRENT OPINION IN NEUROBIOLOGY
卷 15, 期 1, 页码 40-48出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.conb.2005.01.010
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资金
- NIA NIH HHS [AG16999] Funding Source: Medline
- NINDS NIH HHS [NS24054, NS38869] Funding Source: Medline
The retrograde communication of neurotrophic signals from axon terminals to neuron cell bodies is crucial for neuron survival and plasticity. Several mechanisms have been proposed in the past, but recent evidence strongly supports the hypothesis that the retrograde propagation of self-regenerating signaling organelles, derived from the endocytosis of activated neurotrophin-bound receptor tyrosine kinases, is the primary mechanism responsible for this long-distance communication.
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