期刊
BEHAVIORAL NEUROSCIENCE
卷 119, 期 1, 页码 329-335出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.119.1.329
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资金
- NIMH NIH HHS [F32 MH073389-03, MH69884, F32 MH073389-01, K01 MH069884, F32 MH073389-02] Funding Source: Medline
This study demonstrates that mice display olfactory-cued fear as measured with both freezing and fear-potentiated startle. Following a preconditioning test to measure any unconditioned responses to odor, mice received 5 pairings of a 10-s odor with a 0.25-s, 0.4-mA footshock. The next day, startle and freezing were measured in the presence and absence of the odor. Both fear measures increased after training with amyl acetate (Experiment 1) and acetophenone (Experiment 2). The enhancement of startle did not occur when the same number of odors and shocks were presented in an Impaired fashion (Experiment 3). Furthermore, mice were able to discriminate between an odor paired with shock and a nonreinforced odor (Experiment 4).
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