期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 62, 期 3, 页码 320-343出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-004-4297-y
关键词
aging; lifespan; aging; lifespan; genetic instability; telomerase; oxidative stress; superoxide dismutase; oxidants; antioxidants; reactive oxygen species; gluthatione; thioredoxin metabolism; calorie restriction; insulin; IGF-1; growth hormone; signaling; Sir; FOXO; p66; klotho; animal models; S.cerevisiae; C. elegans; D. melanogaster; mouse; knockout; human; syndrome; Ames Dwarf; Snell Dwarf; FIRKO
资金
- NIDDK NIH HHS [DK 45935, DK 33201, DK 60837] Funding Source: Medline
There are many theories of aging and parameters that influence lifespan, including genetic instability, telomerase activity and oxidative stress. The role of caloric restriction, metabolism and insulin and insulin-like growth factor-1 signaling in the process of aging is especially well conserved throughout evolution. These latter factors interact with each other, the former factors and histone deacetylases of the SIR family in a complex interaction to influence lifespan.
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