期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 20, 期 2, 页码 305-317出版社
WILEY
DOI: 10.1359/JBMR.041112
关键词
vitamin D receptor; retinoid X receptor; co-activators; cycling; vitamin D antagonist; chromatin immunoprecipitation
资金
- NIDDK NIH HHS [DK-52453] Funding Source: Medline
1,25(OH)(2)D-3 induces gene expression through the VDR. We used chromatin immunoprecipitation techniques to explore this 1,25(OH)(2)D-3-induced process on the 25-hydroxyvitamin D-3-24-hydroxylase (Cyp24) and Opn gene promoters in intact osteoblasts. Our studies show that 1,25(OH)(2)D-3-induced transactivation is a dynamic process that involves promoter-specific localization of VDR and RXR, recruitment of histone acetyltransferase complexes, and in the case of the Cyp24 gene, modification of histone 4.
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