期刊
JOURNAL OF IMMUNOLOGY
卷 174, 期 3, 页码 1501-1506出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.174.3.1501
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资金
- NCI NIH HHS [CA 093615] Funding Source: Medline
- NIAID NIH HHS [AI 322592, AI 43620] Funding Source: Medline
In order for humoral immune responses to develop, B cells must be able to recognize, bind. and internalize A. These functions are performed by the BCR, which is also responsible for initiating and transducing activation signals necessary for B cell proliferation and differentiation. We have examined surface expression patterns of individual components of the BCR following anti-Ig- and Ag-induced aggregation. Specifically, the localization and expression levels of the Ag-binding component. surface. Ig (sIg), and the Igbeta component of the Igalpha/Igbeta signaling unit were investigated to determine their individual participation in the internalization and signal transduction. Using primary murine B cells, we found that while >95%, of the sIg is internalized following anti-Ig-induced aggregation, 20-30% of Igbeta remains on the surface. These results suggest that sIg and Igbeta may function independently following the initial stages of signal transduction.
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