期刊
JOURNAL OF BIOSCIENCES
卷 30, 期 1, 页码 93-102出版社
INDIAN ACAD SCIENCES
DOI: 10.1007/BF02705154
关键词
gene-environment interactions; low penetrance genes; multiple primary cancers; SNP
类别
Role of heredity and lifestyle in sporadic cancers is well documented. Here we focus on the influence of low penetrance genes and habits, with emphasis on tobacco habit in causing head and neck cancers. Role of such gene-environment interaction can be well studied in individuals with multiple primary cancers. Thus such a biological model may elucidate that cancer causation is not solely due to genetic determinism but also significantly relies on lifestyle of the individual.
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