期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 15, 期 3, 页码 761-764出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2004.11.011
关键词
Akt; PKB; kinase cancer
This letter describes the development of two series of potent and selective allosteric Akt kinase inhibitors that display an unprecedented level of selectivity for either Akt1, Akt2 or both Akt1/Akt2. An iterative analog library synthesis approach quickly provided a highly selective Akt1/Akt2 inhibitor that induces apoptosis in tumor cells and inhibits Akt phosphorylation in vivo. (C) 2004 Elsevier Ltd. All rights reserved.
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