期刊
BEHAVIORAL NEUROSCIENCE
卷 119, 期 1, 页码 280-292出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.119.1.280
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资金
- NIMH NIH HHS [R01 MH065327, R01 MH065327-03, K02 MH068016-03, K02 MH068016, R03MH062471] Funding Source: Medline
Predator odors have been shown to elicit stress responses in rats. The present studies assessed the use of domestic ferret odor as a processive stress model. Plasma corticosterone and adrenocorticotropin hormone levels were higher after 30 min of exposure to ferret odor (fur/skin) but not control odors, ferret feces, urine, or anal gland secretions. Behavioral differences were also found between ferret and the control odors as tested in a defensive withdrawal paradigm. In addition, c-fos messenger RNA expression in several brain areas previously associated with processive stress was significantly higher in ferret odor-exposed rat brains than in control odor-exposed brains. These results suggest that ferret odor produces a reliable unconditioned stress response and may be useful as a processive stress model.
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