期刊
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
卷 43, 期 2, 页码 287-293出版社
WILEY
DOI: 10.1016/j.femsim.2004.09.009
关键词
Propionibacterium acnes; Listeria monocytogenes; cytokine; macrophages; Toll-like receptor
Mice sensitized with Propionibacteritun acnes showed an enhanced resistance against infection with Listeria monocytogenes in contrast to the increased susceptibility to LPS-induced endotoxin shock. The enhanced protection to L. monocytogenes was mediated by activated innate immunity but not by generation of Listeria-specific acquired immunity. After infection with L. monocytogenes, the elimination of bacteria was observed earlier in accordance with a higher level of endogenous cytokine production in P. acnes-sensitized mice than in control mice. Peritoneal cells from P. acnes-sensitized mice produced a larger amount of IL12p70 and nitric oxide after stimulation with heat-killed L. monocytogenes or peptideglycan purified from Staphylococcus aureus. RT-PCR analysis showed that the expression of TLR2 but not TLR1, TLR4 nor TLR6 was induced by injection of P. acnes in peritoneal cells. These results indicated that P. acnes-sensitization could induce the activation of innate immunity against L. monocytogenes through increased recognition of bacterial components by TLR2. (C) 2004 Federation of European Microbiological Societies. Published by Elsevier B.V. All rights reserved.
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