期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 20, 期 2, 页码 232-239出版社
WILEY
DOI: 10.1359/JBMR.041110
关键词
genetic research; epidemiology; osteoporosis; hormones and receptors; menopause
资金
- NIAMS NIH HHS [R03 AR049401] Funding Source: Medline
- NICHD NIH HHS [K12 HD001459, K12 HD01459] Funding Source: Medline
In this study, we evaluated the effect of polymorphisms of the CYP1A1 gene, linked to hormone-related cancers, on estrogen metabolism and BMD. We found that variants carrying the A allele (CA and AA) for the C4887A polymorphism have a significantly higher degree of estrogen catabolism and lower femoral BMD.
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