期刊
MAGNETIC RESONANCE IN MEDICINE
卷 53, 期 2, 页码 249-255出版社
WILEY
DOI: 10.1002/mrm.20374
关键词
prostate; dynamic contrast-enhanced MRI; cancer; benign prostatic hyperplasia; motion
资金
- NCI NIH HHS [T32 CA66527, R01-CA59897] Funding Source: Medline
- NCPDCID CDC HHS [NCI K01CA76998] Funding Source: Medline
This study characterized dynamic contrast-enhanced (DCE) MRI of prostate tissues: cancerous peripheral zone (PZ), normal PZ, stromal benign prostatic hyperplasia (BPH), and glandular BPH. MRI, MRSI, and DCE MRI were performed on 25 patients. Tissues were identified with MRI, MRSI, and (when available) biopsy results. Motion between MRI and DCE MRI, and within DCE MRI was assessed and manually corrected. To assess tissue and patient effects, native T-1's were measured in 12 of 25 patients, and DCE MRI results were normalized to muscle enhancement. Regions of cancer had a higher peak enhancement (P < 0.006), faster enhancement rate (P < 0.0008), and faster washout slope (P < 0.05) than normal PZ tissues. Stromal BPH had the fastest enhancement rate (P < 0.003) of all tissues and tended to have the greatest enhancement. Intersequence motion averaged 2.6 mm and reached 7.9 mm. Motion within DCE MRI was generally minimal (< 2 pixels), but one case showed a large shift that would have confounded the results. Native T-1's were similar across the prostatic tissues. Interpatient variability in DCE MRI was only partially reduced by normalization to muscle. DCE MRI of the prostate discriminated PZ cancer from normal PZ tissues and predominantly stromal and glandular BPH. (C) 2005 Wiley-Liss, Inc.
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