期刊
JOURNAL OF CLINICAL VIROLOGY
卷 32, 期 2, 页码 75-85出版社
ELSEVIER
DOI: 10.1016/j.jcv.2004.05.008
关键词
hepatitis C virus; T cell response; T cell failure; immunopathogenesis
类别
资金
- NCI NIH HHS [R01-CA76403] Funding Source: Medline
- NIAID NIH HHS [R01-AI20001] Funding Source: Medline
Hepatitis C virus (HCV) is a hepatotropic RNA virus that causes acute and chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. It is widely accepted that cellular immune responses play an important role in viral clearance and disease pathogenesis. However, HCV often evades effective immune recognition and has a propensity to persist in the majority of acutely infected individuals (ca. 80%). The immunological and virological basis for the inefficiency of the cellular immune response to clear or control the virus is not known. Recent studies, however, have provided new insights into the mechanisms of viral clearance and persistence that will be discussed in detail. (C) 2004 Elsevier B.V. All rights reserved.
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