期刊
JOURNAL OF HEART AND LUNG TRANSPLANTATION
卷 24, 期 2, 页码 190-194出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.healun.2004.11.006
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Background: While Tacrolimus (Tac) and Cyclosporine (Cya) immunosuppression, are used after cardiac transplantation (tx), few studies, have evaluated their use in pediatric patients. Methods:. We randomized 26 heart transplant recipients (pts) in a prospective, open-label trial to Tac (n = 14), or Cya (n = 12) to compare their efficacy and side-effects. Mean age at tx was 4.2 years for Tac and 5.8 years for Cya. Mean follow-up was 26 months (range: 11-39 months) for Tac and 24 months for Cya (range: 33-13 months). Results: Our data suggest that both regimens are efficacious in the pediatric population. Conversion from Cya to Tac was useful for dealing with persistent rejection, although this sample did not suggest lower incidence of acute cellular rejection in the Tac group. Conclusions: Further studies are required to establish pharmacokinetic parameters to enhance therapeutic monitoring of these patients to minimize side effects and enhance outcomes. Copyright (C) 2005 by the International Society for Heart and Lung Transplantation.
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