Preimplantation genetic diagnosis for aneuploidy screening in patients with unexplained recurrent miscarriages

Objective: To determine the aneuploidy rate in embryos of women with idiopathic revaluate whether preimplantation genetic diagnosis for aneuploidy screening could improve the possibility of successful pregnancy in these couples. Design: Prospective cohort study. Setting: Tertiary university referral center. Patient(s): Women (n = 49) with recurrent idiopathic miscarriages. Intervention(s): In vitro fertilization with preimplantation genetic diagnosis for aneuploidy screening. Main Outcome Measure(s): ongoing pregnancy rate (PR) and aneuploidy rate. Result(s): The aneuploidy rate was, respectively, 43,85% and 66,95% in the you ongoing PR per cycle was 25.71% in the younger and 2.94% in the older patients. Conclusion(s): There is no therapeutic evidence to prescribe IVF with or without diagnosis for aneuploidy screening for this heterogeneous group of patients. (Fertil Steril(R) 2005;83:393-7. (C) 2005 by American Society for Reproductive Medicine).