期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 347, 期 2-3, 页码 289-302出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.200404283
关键词
alcohols; diamines; homogeneous catalysis; hydrosilylation; PMHS; zinc
The Zn-promoted direct reduction of various ketones, including alkyl aryl ketones, alpha- and beta-keto esters, alpha- and beta-keto amides, into the corresponding alcohols with polymethylhydrosiloxane (PMHS) in protic conditions is reported. The reaction proceeds chemoselectively under smooth conditions, with simple catalyst combinations based on a zinc precursor [ZnEt2, Zn(OMe)(2), Zn(OH)(2)] and a 1,2-diamine ligand, e.g., N,N'-dibenzylethylenediamine (dbea). The reaction rates are significantly faster than under aprotic conditions. For beta-keto esters and amides, the use of an excess of PMHS is required. Moderate enantioselectivities (ee up to 55%) have been obtained using a variety of enantiopure diamine ligands. Two mechanisms are proposed for the new catalytic reaction, on the basis of the synthesis of [(diamine)Zn(alkoxide)(2)] complexes which are models of the possible reaction intermediates and a study of their activity.
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