期刊
JOURNAL OF IMMUNOLOGY
卷 174, 期 3, 页码 1269-1273出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.174.3.1269
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资金
- NIAID NIH HHS [AI30048] Funding Source: Medline
- NIGMS NIH HHS [T32 GM008169] Funding Source: Medline
Proliferative renewal of memory CD8 T cells is essential for maintaining long-term immunity. In this study, we examined the contributions that various tissue microenvironments make toward the homeostatic proliferation of Ag-specific memory CD8 T cells. We found that dividing memory T cells were present in both lymphoid and nonlymphoid tissues. However, the bone mar-row was the preferred site for proliferation and contained a major pool of the most actively dividing memory CD8 T cells. Adoptive transfer studies indicated that memory cells migrated through the bone marrow and divided there preferentially. These results show that the bone marrow is not only the source of stem cells for generating naive T cells but also pro-tides the necessary, Signals for the self-renewal of memory T cells.
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