期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 16, 期 1, 页码 129-136出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2004.11.001
关键词
GATA-1; GATA-2; gene regulatory networks; complementation rescue
The hierarchical gene regulatory network in hernatopoiesis is highly complex, making elucidation of the processes of specification and differentiation of hematopoietic cells a challenging task. Recent discoveries have divulged the GATA factors as central to the genetic control of hematopoiesis. In particular, hematopoietic development is subject to extensive and precise regulation of GATA-1 and GATA-2 at the molecular level. We wish to emphasize the regulatory relationships between GATA-1 and GATA-2 implicated in cell development. An advanced experimental genetic approach has provided evidence that abnormalities in this network may result in a variety of blood disorders. The most striking new finding is the novel pathogenesis arising from GATA-1 dysfunction that leads to leukemia. (C) 2004 Elsevier Ltd. All rights reserved.
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