期刊
NATURE REVIEWS MOLECULAR CELL BIOLOGY
卷 6, 期 2, 页码 127-138出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm1568
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In the RNA-interference pathway, double-stranded RNA induces sequence-specific mRNA degradation through the action of the RNA-induced silencing complex ( RISC). Recent work has provided our first glimpses of the RISC-assembly pathway and uncovered the biochemical roles of critical RISC components. These advances have taken our mechanistic understanding of RNA interference to a new level and promise to improve our ability to exploit this biological process for use in experimental biology and medicine.
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