期刊
VIRUS RESEARCH
卷 107, 期 2, 页码 215-228出版社
ELSEVIER
DOI: 10.1016/j.virusres.2004.11.011
关键词
HIV-1; retroviruses; lethal mutagenesis
类别
资金
- NCI NIH HHS [CA39903] Funding Source: Medline
- NIAID NIH HHS [AI34834, AI10139, AI42570] Funding Source: Medline
HIV-1 and other retroviruses exhibit mutation rates that are 1,000,000-fold greater than their host organisms. Error-prone viral replication may place retroviruses and other RNA viruses near the threshold of error catastrophe or extinction due to an intolerable load of deleterious mutations. Strategies designed to drive viruses to error catastrophe have been applied to HIV-1 and a number of RNA viruses. Here, we review the concept of extinguishing HIV infection by lethal mutagenesis and consider the utility of this new approach in combination with conventional antiretroviral strategies. (C) 2004 Published by Elsevier B.V.
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