期刊
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
卷 288, 期 2, 页码 G403-G406出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpgi.00357.2004
关键词
ulcerative colitis
资金
- NIDDK NIH HHS [R-01-DK-061417, R-01-DK-002802, R24-DK-064399] Funding Source: Medline
Crohn's disease (CD) is driven by seemingly aberrant immune responses directed toward commensal enteric microflora. However, the specific antigens targeted by this immune response remain largely undefined. Herein, we demonstrate that common enteric flagellins are one such target of the CD-associated immune response. Thus flagellin may not only drive acute inflammation via activation of Toll-like receptor 5-mediated gene expression but may also serve as a target of the adaptive immune response that maintains the chronic inflammation characteristic of CD.
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