期刊
SEMINARS IN CANCER BIOLOGY
卷 15, 期 1, 页码 3-12出版社
ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2004.09.006
关键词
karyotyping; numerical chromosome changes; aneuploidy; chromosome instability; clonal evolution
类别
Several neoplastic tumor types are cytogenetically characterized by multiple numerical chromosome abnormalities without concomitant structural karyotypic changes. At present, no good gene-level theories are at hand to explain the pathogenetic effect of these changes during tumorigenesis. nor is it known how they arise or what causes them. Genetic instability is often invoked as an underlying cause. but actual data favoring this explanation are meager or non-existing. Numerical chromosome changes and ploidy shifts allow the simultaneous alteration of multiple cancer-relevant genes, thereby reducing the number of independent genomic events necessary for carcinogenesis and the need for postulating genomic instability as a necessity in cancer development. (C) 2004 Elsevier Ltd. All rights reserved.
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