期刊
CELLULAR AND MOLECULAR NEUROBIOLOGY
卷 25, 期 1, 页码 181-199出版社
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s10571-004-1383-x
关键词
HIV; AIDS; blood-brain barrier; brain endothelial cells; inflammatory responses; tight junction; Tat
资金
- NIAAA NIH HHS [AA013843] Funding Source: Medline
- NIEHS NIH HHS [P42 ES007380] Funding Source: Medline
- NIMH NIH HHS [MH63022] Funding Source: Medline
- NINDS NIH HHS [NS39254] Funding Source: Medline
1. Alterations of brain microvasculature and the disruption of the blood-brain barrier (BBB) integrity are commonly associated with human immunodeficiency virus type 1 (HIV-1) infection. These changes are most frequently found in human immunodeficiency virus-related encephalitis (HIVE) and in human immunodeficiency virus-associated dementia (HAD). 2. It has been hypothesized that the disruption of the BBB occurs early in the course of HIV-1 infection and can be responsible for HIV-1 entry into the CNS. 3. The current review discusses the mechanisms of injury to brain endothelial cells and alterations of the BBB integrity in HIV-infection with focus on the vascular effects of HIV Tat protein. In addition, this review describes the mechanisms of the BBB disruption due to HIV-1 or Tat protein interaction with selected risk factors for HIV infection, such as substance abuse and aging.
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