期刊
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
卷 192, 期 2, 页码 554-557出版社
MOSBY, INC
DOI: 10.1016/j.ajog.2004.09.001
关键词
Porphyromonas gingivalis; periodontal disease; rabbit; pregnancy
资金
- NICHD NIH HHS [1 K08 HD043284-01, 5 K12 HD01441-03] Funding Source: Medline
Objective: This study was undertaken to develop a rabbit model of maternal exposure to Porphyromonas gingivalis and determine whether fetal or placental exposure occurs. Study design: Subcutaneous steel chambers were implanted in 8 New Zealand White female rabbits. On day 7 of pregnancy, 4 rabbits were inoculated through the chamber with 5 X 10(8) CFU/mL live P gingivalis, and 4 rabbits with broth (controls) and sacrificed at term. Polymerase chain reaction was used to detect P gingivalis in maternal and fetal liver and placenta. Fisher exact test was used to compare P gingivalis detection between groups. Results: Among exposed does, P gingivalis was detected in 33% of the maternal livers, 49% of placentas, and 34% fetal livers compared with none from controls (P < .001). Conclusion: Chronic maternal exposure to P gingivalis results in systemic dissemination, transplacental passage, and fetal exposure. This model may be useful to study placental and fetal effects of this oral pathogen and to study microbial dissemination across the placenta. (C) 2005 Elsevier Inc. All rights reserved.
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