Oseltamivir (Tamiflu®) and its potential for use in the event of an influenza pandemic

Recent cross species transmission of avian influenza has highlighted the threat of pandernic influenza. Oseltarnivir(Tamiflue) has been shown to be effective in the treatment and prevention of epidemic influenza infection in adults, adolescents and children ( A year). Although oseltarnivir has not been approved for prophylactic use in children, it has been shown to be effective. Oseltarnivir is also active against avian influenza virus strains. Evidence suggests that lower doses or shorter durations of treatment/chemoprophylaxis other than those approved may not be effective and may contribute to emergence of viral resistance. Safety data from dose ranging studies show that 5 day courses of 150 mg twice daily for treatment and 6 week courses of 75 mg twice daily for prophylaxis were as well tolerated as the approved dose regimens. The use of oseltamivir in a pandemic is influenced by the goals of the pandernic plan developed by the responsible Government and Health Authority. To optimize use of antiviral medications, processes will be needed to collect, collate and report outcome data from treated patients and/or from use for chernoprophylaxis of pandemic influenza during the first-wave outbreaks. If oseltarnivir is included in a national or regional pandernic plan, stockpiling of the material, either in the form of capsules or the bulk active pharmaceutical ingredient will be necessary. In the absence of a stockpile, there is no guarantee that an adequate supply of oseltarnivir will be available.