期刊
MOLECULAR IMMUNOLOGY
卷 42, 期 4, 页码 451-454出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.molimm.2004.07.025
关键词
NK cells; innate immunity; costimulation
资金
- NCI NIH HHS [CA89294] Funding Source: Medline
NK cells promote adaptive immune responses through their production of type I and type 2 cytokines or chemokines. Secretion of these factors by activated NK cells influences the differentiation of B and T lymphocytes. Increasing evidence indicates that NK cells are also directly involved in dendritic cell (DC) maturation. By contrast, a potential role for direct cell-cell interactions between NK and T lymphocytes, in particular CD4(+) T cells, has not been explored. We provide evidence that activated human NK cells are able of promoting TcR-dependent proliferation of resting autologous peripheral blood CD4(+) T cells by a process that involves costimulatory molecules of the immunoglobulin (Ig) and tumor necrosis factor (TNF) superfamilies. These findings suggest a novel link between natural and adaptative immune responses. (C) 2004 Elsevier Ltd. All rights reserved.
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