期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 70, 期 3, 页码 1042-1045出版社
AMER CHEMICAL SOC
DOI: 10.1021/jo048469q
关键词
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A modular, one-pot, two-step, four-component synthesis of polysubstituted 1,3-oxzolidines is described. The method comprises two linked domino processes: an organocatalyzed domino reaction of alkyl propiolate and an aliphatic aldehydes and a microwave-assisted amine addition cyclization domino process. An alternative modular, one-pot, three-step, four-component synthesis has also been developed by linking the organocatalyzed domino process to a sequential amine addition/Yb(OTf)(3)-catalyzed enamine cyclization reaction.
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